Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran

(2021) Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran. Scientific Reports. p. 6. ISSN 2045-2322

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Abstract

Risk factors for clinical outcomes of COVID-19 pneumonia have not yet been well established in patients with underlying liver diseases. Our study aimed to describe the clinical characteristics and outcomes of COVID-19 infection among patients with underlying liver diseases and determine the risk factors for severe COVID-19 among them. In a retrospective analytical study, 1002 patients with confirmed COVID-19 pneumonia were divided into two groups: patients with and without underlying liver diseases. The admission period was from 5 March to 14 May 2020. The prevalence of underlying conditions, Demographic data, clinical parameters, laboratory data, and participants' outcomes were evaluated. Logistic regression was used to estimate the predictive factors. Eighty-one (8) of patients had underlying liver diseases. The frequencies of gastrointestinal symptoms such as diarrhea and vomiting were significantly higher among patients with liver diseases (48 vs. 25 and 46.1 vs. 30 respectively, both P<0.05). Moreover, ALT and AST were significantly higher among patients with liver diseases (54.5 +/- 45.6 vs. 37.1 +/- 28.4, P=0.013 and 41.4 +/- 27.2 vs. 29.2 +/- 24.3, P=0.028, respectively). Additionally, the mortality rate was significantly high in patients with liver disease (12.4 vs. 7, P=0.018). We also observed that the parameters such as neutrophil to leukocyte ratio Odds Ratio Adjusted (ORAdj) 1.81, 95% CI 1.21-3.11, P=0.011 and blood group A (ORAdj 1.59, 95% CI 1.15-2.11, P=0.001) were associated with progression of symptoms of COVID-19. The presence of underlying liver diseases should be considered one of the poor prognostic factors for worse outcomes in patients with COVID-19.

Item Type: Article
Keywords: receptor protein Science & Technology - Other Topics
Page Range: p. 6
Journal or Publication Title: Scientific Reports
Journal Index: ISI
Volume: 11
Number: 1
Identification Number: https://doi.org/10.1038/s41598-021-82721-3
ISSN: 2045-2322
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9567

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