Abstract

Background: The present study was aimed at evaluating the effect of on-demand caffeine consumption on treating patients with premature ejaculation (PE compared to squeezing technique. Methods: In this non-blind RCT, 42 otherwise healthy individuals with PE were divided into 2 groups of caffeine and squeezing technique group. The former received 100 mg of encapsulated caffeine for 3 weeks, 2 hours prior to each intercourse. Intra-vaginal ejaculation latency time and index of sexual satisfaction were calculated before and after treatment in both groups. Results: Mean age of the participants was 39.48 +/- 7.62 years. Despite the fact that there was no significant difference between pre-treatment and post-treatment values of both IELT and ISS between our 2 groups, significant difference was seen in both groups between pre-treatment and post-treatment values. Furthermore, no strong correlation was seen in pre-treatment IELT and ISS; however, statistically significant correlation was found in post-treatment values. Conclusion: Regarding the fact that caffeine is a well-known and widely-used drug in common disease, the use of this compound is highly unlikely to bear any stigma. Our study demonstrates that 100 mg of on-demand caffeine can equally increase both IELT and ISS significantly as squeezing technique. Further investigations are needed.