Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Current natural bioactive materials in bone and tooth regeneration in dentistry: a comprehensive overview

(2021) Current natural bioactive materials in bone and tooth regeneration in dentistry: a comprehensive overview. Journal of Materials Research and Technology-Jmr&T. pp. 2078-2114. ISSN 2238-7854

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Abstract

Tissue regeneration is a vital phenomenon in the skeletal system of human beings during their life span. The structure of bony architecture and teeth are highly dependent to this ongoing procedure to maintain their functional form. Regarding the fundamental function of our skeletal system, all the involved components are at constant risk for injuries and deformations throughout the life. Therefore, in modern medicine, promotion of bone and tooth regeneration has become a critical counter measure to correct these acquired defects. There are numerous ways to address the bone and tooth related erosive pathologies but utilization of natural compounds has gained immense popularity in recent years. These materials provide a broad spectrum of therapeutic agents with a variety of biological characteristics. In this review, a comprehensive exploration has been implemented to extract and categorize the relevant scientific evidence on this issue, based on the source of natural candidates and the potential clinical indications. Database searching presented a considerable data pool with more than 300 references in this field. According to the results, all the proposed items can be categorized in two major groups including scaffolding and osteogenesis (or dentinogenesis) induction. The clinical applicability of a number of them is properly demonstrated in clinical trials but for the rest, more examinations are required to reach a conclusive decision. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Item Type: Article
Keywords: Natural Bioactive materials Regeneration Bone Tooth mesenchymal stem-cells human periodontal-ligament mineral trioxide aggregate acid phenethyl ester in-vitro properties green tea catechin dental-pulp cells osteogenic differentiation alveolar bone chlorogenic acid Materials Science Metallurgy & Metallurgical Engineering
Page Range: pp. 2078-2114
Journal or Publication Title: Journal of Materials Research and Technology-Jmr&T
Journal Index: ISI
Volume: 13
Identification Number: https://doi.org/10.1016/j.jmrt.2021.05.089
ISSN: 2238-7854
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9706

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