Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Decellularized and biological scaffolds in dental and craniofacial tissue engineering: a comprehensive overview

(2021) Decellularized and biological scaffolds in dental and craniofacial tissue engineering: a comprehensive overview. Journal of Materials Research and Technology-Jmr&T. pp. 1217-1251. ISSN 2238-7854

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Abstract

Dental problems including cavities, periodontitis, apical periodontitis, and pulpitis are among the most cost-consuming burden for both patients and the health care system all over the world. The pathological consequences of these complications importantly lead to tooth loss causing functional and psychological conflictions for patients. The traditional treatment includes removing the impaired tooth or its restoration using hard restorative materials that are supposed to mimic the tissue of enamel or dentine whereas these materials cannot simulate the chemical, biological, or physical characteristics of a natural tooth. Therefore, different daily-progressing methods of tissue engineering (TE) are being propounded as new and promising approaches for managing dentistry conflicts. TE is now considered almost a practical, reproducible, and clinically safe therapy for regenerating different oral and dental tissues including either the whole dental organ or its various anatomical parts. TE necessarily constitutes three angles of stem cell (SC), scaffold, and essential growth factors (GFs). Generally, scaffolds can be made of decellularized scaffolds (usually containing the extra-cellular matrix (ECM) of target organs and tissues) or biologic scaffolds (containing natural polymer). The current study aims to review the studies conducted in the recent decade on decellularized and biological scaffolds and their po-tential applications in modern regenerative dentistry. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Item Type: Article
Keywords: Iran Biological scaffold Decellularized scaffold Dental tissue engineering mesenchymal stem-cells platelet-rich fibrin calcium-phosphate cement fibroblast growth factor-2 human umbilical-cord exfoliated deciduous teeth critical-sized defects marrow stromal cells periodontal-ligament bone regeneration Materials Science Metallurgy & Metallurgical Engineering
Page Range: pp. 1217-1251
Journal or Publication Title: Journal of Materials Research and Technology-Jmr&T
Journal Index: ISI
Volume: 15
Identification Number: https://doi.org/10.1016/j.jmrt.2021.08.083
ISSN: 2238-7854
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9774

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