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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Changes in mitochondrial biogenesis and fatty liver indicators in rat following continuous and high intensity interval training

(2021) Changes in mitochondrial biogenesis and fatty liver indicators in rat following continuous and high intensity interval training. Journal of Sports Medicine and Physical Fitness. pp. 1416-1422. ISSN 0022-4707

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Abstract

BACKGROUND: Oxidative stress and mitochondrial dysfunction can be tracked down in most liver diseases like non-alcoholic fatty liver disease (NAFLD). The most recommended preventative method is lifestyle modification, especially exercise. The aim of this study was the investigation of changes in the indexes of mitochondrial biogenesis and fatty liver indicators in rat following continuous and high intensity interval training. METHODS: Thirty healthy male rats were divided into three control (C=10), Continuous swimming training (CT=10) and High intensity interval swimming training groups (HIIT=10). The training groups performed their specific exercises 5 days a week for 8 weeks. 24 h after the last training session in order to prepare the serum, a blood sample was taken from the left ventricle of the rats. In addition, liver tissue was extracted and the SIRT3, PGC-1 alpha, GSH:GSSG, MDA, LDL, HDL, LDL:HDL, TG, TC, AST, ALT and FBS variables were measured by ELISA and analysis of blood biochemistry. RESULTS: Continuous training (CT) increased the levels of PGC-1 alpha, SIRT3 and significantly reduced LDL, LDL:HDL, TG and FBS (P<0.05) levels. High-intensity interval training (HIIT) caused a significant increase in SIRT3 and a significant decrease in FBS (P<0.05) levels. CONCLUSIONS: Adaptations resulting from further aerobic exercise can increase mitochondrial biogenesis factors such as PGC-1 alpha and SIRT3 in hepatocytes, improve this process in hepatocytes, and ultimately improve the fatty liver markers. Therefore, CT may be more effective than HIIT in preventing fatty liver disease.

Item Type: Article
Keywords: Free radicals High-intensity interval training Organelle biogenesis Non-alcoholic fatty liver Sirtuin 3 calorie restriction acid oxidation exercise sirt3 capacity muscle susceptibility disease model Sport Sciences
Page Range: pp. 1416-1422
Journal or Publication Title: Journal of Sports Medicine and Physical Fitness
Journal Index: ISI
Volume: 61
Number: 10
Identification Number: https://doi.org/10.23736/s0022-4707.20.11693-1
ISSN: 0022-4707
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9781

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