Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update

(2021) Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update. Mini-Reviews in Medicinal Chemistry. pp. 899-918. ISSN 1389-5575

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Abstract

In modern dentistry, nanomaterials have strengthened their foothold among tissue engineering strategies for treating bone and dental defects due to a variety of reasons, including trauma and tumors. Besides their finest physiochemical features, the biomimetic characteristics of nanomaterials promote cell growth and stimulate tissue regeneration. The single units of these chemical substances are small-sized particles, usually between 1 to 100 nm, in an unbound state. This unbound state allows particles to constitute aggregates with one or more external dimensions and provide a high surface area. Nanomaterials have brought advances in regenerative dentistry from the laboratory to clinical practice. They are particularly used for creating novel biomimetic nanostructures for cell regeneration, targeted treatment, diagnostics, imaging, and the production of dental materials. In regenerative dentistry, nanostructured matrices and scaffolds help control cell differentiation better. Nanomaterials recapitulate the natural dental architecture and structure and form functional tissues better compared to the conventional autologous and allogenic tissues or alloplastic materials. The reason is that novel nanostructures provide an improved platform for supporting and regulating cell proliferation, differentiation, and migration. In restorative dentistry, nanomaterials are widely used in constructing nanocomposite resins, bonding agents, endodontic sealants, coating materials, and bioceramics. They are also used for making daily dental hygiene products such as mouth rinses. The present article classifies nanostructures and nanocarriers in addition to reviewing their design and applications for bone and dental regeneration.

Item Type: Article
Keywords: Nanomaterial nanoparticle regenerative dentistry dental regeneration bone regeneration bone regeneration carbon nanotubes sodium hyaluronate gold nanoparticles alveolar bone periodontal regeneration nano-hydroxyapatite drug-delivery stem-cells scaffolds Pharmacology & Pharmacy
Page Range: pp. 899-918
Journal or Publication Title: Mini-Reviews in Medicinal Chemistry
Journal Index: ISI
Volume: 21
Number: 7
Identification Number: https://doi.org/10.2174/1389557520666201124143449
ISSN: 1389-5575
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9801

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