Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight

(2021) Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight. International Journal of Stem Cells. pp. 351-365. ISSN 2005-3606

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Abstract

The interactions between the tumor microenvironment and the tumor cells confers a condition that accelerate or decelerate the development of tumor. Of these cells, mesenchymal stem cells (MSCs) have the potential to modulate the tumor cells. MSCs have been established with double functions, whereby contribute to a tumorigenic or anti-tumor setting. Clinical studies have indicated the potential of MSCs to be used as tool in treating the human cancer cells. One of the advantageous features of MSCs that make them as a well-suited tool for cancer therapy is the natural tumor-trophic migration potential. A key specification of the tumor development has been stablished to be angiogenesis. As a result, manipulation of angiogenesis has become an attractive approach for cancer therapy. This review article will seek to clarify the anti-angiogenesis strategy in modulating the MSCs to treat the tumor cells.

Item Type: Article
Keywords: Mesenchymal stem cells Angiogenesis Cancer therapy Tumor microenvironment endothelial growth-factor umbilical-cord blood human bone-marrow tyrosine kinase inhibitor double-edged-sword stromal cells in-vitro lung-cancer progesterone-receptors tissue distribution Cell Biology
Page Range: pp. 351-365
Journal or Publication Title: International Journal of Stem Cells
Journal Index: ISI
Volume: 14
Number: 4
Identification Number: https://doi.org/10.15283/ijsc20146
ISSN: 2005-3606
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9854

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