Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Sensitive sensor based on TiO(2)NPs nano-composite for the rapid analysis of Zolpidem, a psychoactive drug with cancer-causing potential

(2021) Sensitive sensor based on TiO(2)NPs nano-composite for the rapid analysis of Zolpidem, a psychoactive drug with cancer-causing potential. Materials Today Communications. p. 10. ISSN 2352-4928

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Abstract

In the present study, a sensitive and specific electrochemical sensor is developed based on titanium dioxide and ionic liquid nano-composite (TiO(2)NPs/IL) for the measurement of Zolpidem (ZLP) as a hypnotic and sleep-promoting drug. The nano-composite provides high surface area and catalytic ability in ZLP oxidation at the modified carbon paste electrode (CPE). The obtained results of the differential pulse voltammetry (DPV) method reflect a wide linear range (0.1 - 90 mu M) and an unprecedented limit of detection (LOD = 33 nM) for the ZLP sensor comparable with previously reported methods. The TiO(2)NPs/IL/CPE remarkably enriched the electrochemical response to ZLP oxidation and it has good stability, repeatability, and reproducibility. The TiO(2)NPs/IL/ CPE is mechanically stable, cost-effective and simple, with suitable electrochemical and adsorption properties in comparison to the pencil graphite electrode (PGE) and glassy carbon electrode (GCE). The potential applicability of the sensor was successfully applied for distinguishing the ZLP in human plasma and drug formulation samples.

Item Type: Article
Keywords: Zolpidem Differential pulse voltammetry Titanium dioxide nanoparticles Ionic liquid Nanocomposite Modified electrode Materials Science
Page Range: p. 10
Journal or Publication Title: Materials Today Communications
Journal Index: ISI
Volume: 26
Identification Number: https://doi.org/10.1016/j.mtcomm.2020.101945
ISSN: 2352-4928
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9856

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