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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Game of "crowning" season 8: RAS and reproductive hormones in COVID-19-can we end this viral series?

(2021) Game of "crowning" season 8: RAS and reproductive hormones in COVID-19-can we end this viral series? Archives of Medical Science. pp. 275-284. ISSN 1734-1922

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Abstract

The outbreak of a newly identified coronavirus, the SARS-CoV-2 (alternative name 2019-nCoV), capable of jumping across species causing zoonosis with severe acute respiratory syndromes (SARS), has alerted authorities worldwide. Soon after the epidemic was first detected in the city of Wuhan in the Hubei Province of China, starting in late December 2019, the virus spread over multiple countries in different continents, being declared a pandemic by March 2020. The demographic characteristics of the infected patients suggest that age, sex, and comorbidities are predictive factors for the fatality of the infection. The mechanisms of viral entry into the human host cells seem to be in a close relationship with the mechanisms of regulating the renin-angiotensin system (RAS), which may explain the pathogenesis associated with the infection. This brings new insights into the possibilities of exploiting viral entry mechanisms to limit associated complications by means of enhancing the resistance of the infected patients using methods of regulating the RAS and strategies of modulating ACE2 expression. In this perspective article we exploit the mechanisms of COVID-19 pathogenesis based on the demographic characteristics of the infected patients reported in the recent literature and explore several approaches of limiting the initial steps of viral entry and pathogenesis based on viral interactions with ACE2 and RAS. We further discuss the implications of reproductive hormones in the regulation of the RAS and investigate the premise of using endocrine therapy against COVID-19.

Item Type: Article
Keywords: SARS-CoV-2 2019-nCoV COVID-19 endocrine therapy ACE2 ARBs mineralocorticoid receptor antagonist ADAM-17 miRNA angiotensin-converting enzyme acute respiratory syndrome sars-coronavirus prostate-cancer 1-7 axis receptor system ace2 pathogenesis sex General & Internal Medicine
Page Range: pp. 275-284
Journal or Publication Title: Archives of Medical Science
Journal Index: ISI
Volume: 17
Number: 2
Identification Number: https://doi.org/10.5114/aoms.2020.96497
ISSN: 1734-1922
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9868

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