Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Harnessing polyphenol power by targeting eNOS for vascular diseases

(2021) Harnessing polyphenol power by targeting eNOS for vascular diseases. Critical Reviews in Food Science and Nutrition. p. 26. ISSN 1040-8398

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Vascular diseases arise due to vascular endothelium dysfunction in response to several pro-inflammatory stimuli and invading pathogens. Thickening of the vessel wall, formation of atherosclerotic plaques consisting of proliferating smooth muscle cells, macrophages and lymphocytes are the major consequences of impaired endothelium resulting in atherosclerosis, hypercholesterolemia, hypertension, type 2 diabetes mellitus, chronic renal failure and many others. Decreased nitric oxide (NO) bioavailability was found to be associated with anomalous endothelial function because of either its reduced production level by endothelial NO synthase (eNOS) which synthesize this potent endogenous vasodilator from L-arginine or its enhanced breakdown due to severe oxidative stress and eNOS uncoupling. Polyphenols are a group of bioactive compounds having more than 7000 chemical entities present in different cereals, fruits and vegetables. These natural compounds possess many OH groups which are largely responsible for their strong antioxidative, anti-inflammatory antithrombotic and anti-hypersensitive properties. Several flavonoid-derived polyphenols like flavones, isoflavones, flavanones, flavonols and anthocyanidins and non-flavonoid polyphenols like tannins, curcumins and resveratrol have attracted scientific interest for their beneficial effects in preventing endothelial dysfunction. This article will focus on in vitro as well as in vivo and clinical studies evidences of the polyphenols with eNOS modulating activity against vascular disease condition while their molecular mechanism will also be discussed.

Item Type: Article
Keywords: Endothelial function eNOS polyphenols vascular diseases nitric-oxide-synthase endothelium-dependent vasodilation green tea polyphenol spontaneously hypertensive-rats redox-sensitive activation induced insulin-resistance porcine coronary-arteries pomegranate fruit extract induced oxidative stress perturbed shear-stress Food Science & Technology Nutrition & Dietetics
Page Range: p. 26
Journal or Publication Title: Critical Reviews in Food Science and Nutrition
Journal Index: ISI
Identification Number:
ISSN: 1040-8398
Depositing User: مهندس مهدی شریفی

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