Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The study of antimicrobial resistance among Shigella flexneri strains isolated in Tehran, Iran

(2011) The study of antimicrobial resistance among Shigella flexneri strains isolated in Tehran, Iran. Journal of Pediatric Infectious Diseases. pp. 125-129. ISSN 13057707 (ISSN)

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Shigellosis is one of the major causes of morbidity in children with diarrhea in Iran. The aim of this study was to investigate antimicrobial resistance of Shigella flexneri (S. flexneri) strains isolated from clinically diagnosed cases of gastroenteritis and acute diarrhea in Tehran, Iran. Shigella strains were isolated from stool samples of patients who visited the several major hospitals in Tehran. S. flexneri was preliminarily identified by biochemical tests as well as by API20E. Antimicrobial resistance testing was performed according to the standard guidelines of the Clinical and Laboratory Standards Institute. All strains were resistant to streptomycin. More than 96.4 of the strains were resistant to tetracycline and amoxicillin, 89 to co-trimoxsazole, 72.6 to ampicillin, 33.3 to chloramphenicol, 9.5 to kanamycin, 1.2 to cefixime, amikacin and furazolidone. None of the tested isolates were resistant to ceftriaxone, ceftizoxime, ceftazidime, gentamicin, ciprofloxacin, cephalothin, cefotaxime, cephalexine, nalidixic acid and nitrofurantoin. More than 96 of the strains showed multi-drug resistance phenotype. Seventeen resistance patterns were identified among the strains, however the most prevalent phenotype (36.9) was R6 (streptomycin/amoxicillin/ tetracycline/co-trimoxsazole/ampicillin). This study indicates an increase in incidence of multiple drug resistance among the strains of S. flexneri isolated in Tehran, Iran. © 2011-IOS Press and the authors. All rights reserved.

Item Type: Article
Keywords: antibiotic resistance Iran multi drug resistance Shigella flexneri amikacin amoxicillin ampicillin cefalexin cefalotin cefixime cefotaxime ceftazidime ceftizoxime ceftriaxone chloramphenicol ciprofloxacin cotrimoxazole furazolidone gentamicin kanamycin nalidixic acid nitrofurantoin streptomycin tetracycline acute diarrhea antibiotic sensitivity article bacterial strain bacterium isolation feces analysis gastroenteritis human major clinical study phenotype priority journal
Page Range: pp. 125-129
Journal or Publication Title: Journal of Pediatric Infectious Diseases
Journal Index: Scopus
Volume: 6
Number: 2
Identification Number:
ISSN: 13057707 (ISSN)
Depositing User: مهندس مهدی شریفی

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