Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Late anemia in pediatric kidney transplant recipients: Prevalence and risk factors

(2011) Late anemia in pediatric kidney transplant recipients: Prevalence and risk factors. Nephrourol Mon. pp. 172-176. ISSN 22517006 (ISSN)

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Background: Anemia is a frequent complication among pediatric transplant recipients. However, limited published studies are currently available about anemia in these patients. Objectives: We conducted a retrospective study to determine the prevalence and risk factors of late post-transplant anemia (PTA) among pediatric kidney transplant patients. Patients and Methods: A total of 78 kidney transplant patients ≤ 18 years old were enrolled. Prevalence of late PTA, beyond 1 year after transplantation, in children was evaluated between 2008 and 2011. We considered anemia as hemoglobin concentration of ≤ 11 mg/dl and less than 10 mg/dl as a severe anemia. Both univariate and multivariate analyses were performed to determine the correlation of PTA with other risk factors such as renal allograft function and other laboratory parameters. Results: The mean age of recipients was 10 ± 3 years (range: 3 to 18 years); 58 male and 42 female. The prevalence PTA in this survey was 15.4 (n = 12). The prevalence of late PTA was not different in both boys and girls (p = 0.38). At univariate analysis, a significant relationship was seen between serum creatinine concentrations and Hb levels (P = 0.005, r = 0.32) and there was also a significant relationship between serum Hb and cyclosporine trough blood level (p = 0.009, r = 0.29) and 2 hour post dose level of cyclosporine (p = 0.03, r = 0.29). At multivariate logistic regression after adjustment for other factors, however, renal allograft impairment was the only a risk factor for late PTA (P = 0.05, EXP (B) = 2.5; 95 CI = 1.0- 6.3). Conclusions: The prevalence of late PTA in our children was lower than previously reported in literature from both adult and pediatric transplant patients. © 2011 Kowsar M.P.Co. All rights reserved.

Item Type: Article
Keywords: Anemia Child Kidney Transplantation creatinine cyclosporin hemoglobin adult article controlled study creatinine blood level drug blood level female graft recipient hemoglobin blood level human kidney graft rejection kidney transplantation major clinical study male renal graft dysfunction retrospective study risk factor
Page Range: pp. 172-176
Journal or Publication Title: Nephrourol Mon
Journal Index: Scopus
Volume: 3
Number: 3
ISSN: 22517006 (ISSN)
Depositing User: مهندس مهدی شریفی

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