Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Comparison of two doses of corticosteroid in epidural steroid injection for lumbar radicular pain

(2007) Comparison of two doses of corticosteroid in epidural steroid injection for lumbar radicular pain. Singapore Medical Journal. pp. 241-245. ISSN 00375675 (ISSN)

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Introduction: Low back pain and lumbar radicular pain are the leading causes of job loss worldwide. Therapeutic approaches to lumbar radicular pain, including sciatica and spinal canal stenosis, are diverse. Many clinicians use 80 mg long-acting glucocorticoids in epidural steroid injections (ESI). The aim of this study is to compare the clinical response of 80 mg versus 40 mg methylprednisolone in ESI. Methods: 84 patients with newly exacer bated lumbar radicular pain were randomly al located into two groups. 43 patients under went ESI with 80 mg Depo-Medrol and 41 age- and sex-matched cases received 40 mg Depo-Medrol as the comparison group. The pain in the second week, and every month thereafter was assessed using a visual analogue scale (VAS). Results: Remarkable improvement in one month VAS occurred in 64 cases (75 percent) from both groups. VAS values between 80 mg and 40 mg groups were comparable in the two-week (p-value is 0.827) and three-month (p-value is greater than 0.746) post-injection periods. Slightly better results were shown in patients in the 40 mg group after one month. Conclusion: In the case of lumbar radicular pain, ESI with low dose (40 mg) methylprednisolone is as effective as high dose (80 mg) with comparable results and less adverse profile.

Item Type: Article
Keywords: Epidural injection Glucocorticoid Herniated disc Radicular pain Steroid injection corticosteroid methylprednisolone methylprednisolone acetate antiinflammatory agent drug derivative adult article clinical trial controlled clinical trial controlled study disease exacerbation drug dose comparison drug efficacy drug megadose epidural abscess epidural hematoma female headache hot flush human hyperglycemia low back pain low drug dose major clinical study male pain assessment randomized controlled trial treatment outcome visual analog scale comparative study epidural drug administration radiculopathy Anti-Inflammatory Agents Glucocorticoids Humans Injections, Epidural Pain Measurement
Page Range: pp. 241-245
Journal or Publication Title: Singapore Medical Journal
Journal Index: Scopus
Volume: 48
Number: 3
ISSN: 00375675 (ISSN)
Depositing User: مهندس مهدی شریفی

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