Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Evaluation of the antioxidant impact of ginger-based kombucha on the murine breast cancer model

(2017) Evaluation of the antioxidant impact of ginger-based kombucha on the murine breast cancer model. J Complement Integr Med. ISSN 1553-3840

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Background Abnormal metabolism is a common event in cancerous cells. For example, the increase of reactive oxygen species (ROS) production, particularly due to aerobic respiration during invasive stage, results in cancer progression. Herein, the impact of kombucha tea prepared from ginger on the alteration of antioxidant agents was assessed in the breast cancer animal model. Methods Two types of kombucha tea with or without ginger were administered to BALB/c mice before and after tumor challenge. Superoxide dismutase (SOD), catalase, glutathione (GSH) and malondialdehyde (MDA) were evaluated in tumor, liver and kidney. Results Administration of kombucha ginger tea significantly decreased catalase activity as well as GSH and MDA level in tumor homogenate (p<0.001). A significant decrease in SOD activity and increase in MDA quantity was determined in the kidney which had received kombucha ginger tea (p<0.01). Conclusions The consumption of kombucha prepared from ginger could exert minor antioxidant impacts by balancing multi antioxidant factors in different tissues in the breast cancer models.

Item Type: Article
Keywords: Animals Antioxidants/*administration & dosage Breast Neoplasms/*drug therapy/genetics/metabolism Disease Models, Animal Drug Evaluation, Preclinical Female Ginger/*chemistry Glutathione/metabolism Humans Kidney/drug effects/metabolism Liver/drug effects/metabolism Malondialdehyde/metabolism Mice Mice, Inbred BALB C Oxidative Stress/drug effects Plant Extracts/*administration & dosage Reactive Oxygen Species/metabolism Superoxide Dismutase/metabolism breast cancer ginger kombucha oxidative stress probiotic
Journal or Publication Title: J Complement Integr Med
Journal Index: Pubmed
Volume: 15
Number: 1
Identification Number:
ISSN: 1553-3840
Depositing User: مهندس مهدی شریفی

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