Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The diagnostic role of microRNA-34a in breast cancer: a systematic review and meta-analysis

(2017) The diagnostic role of microRNA-34a in breast cancer: a systematic review and meta-analysis. Oncotarget. pp. 23177-23187. ISSN 1949-2553

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BACKGROUND: MicroRNA-34a (miR-34a) is a master regulator of tumor suppression in breast cancer (BC). This systematic review aims to analyze the diagnostic accuracy of miR-34a in the detection of BC as a biomarker. RESULTS: A total of 1858 BC cases and 494 controls from thirteen eligible studies reported in 9 publications were included. The overall pooled sensitivity, specificity, negative likelihood ratio (NLR), positive likelihood ratio (PLR), and diagnostic odds ratio (DOR) were 85.50 (95 CI: 83.80-87.00), 70.00 (95 CI: 65.80-74.10), 0.29 (95 CI: 0.19-0.43), 2.58 (95 CI: 1.91-3.43), and 9.39 (95 CI: 5.47-16.12), respectively. Similarly, the overall area under the curve (AUC) of the summary receiver operating characteristic (SROC) was 0.80, indicating the high conservation of miR-34a as a biomarker. Furthermore, subgroup analysis suggested that the use of miR-34a as a biomarker is more accurate in tissue-based sample of invasive BC. We also indicated that miR-34a is a capable biomarker in diagnosing BC in people of Caucasian descent. MATERIALS AND METHODS: A systematic search was conducted for eligible publications that address miR-34a expression level in BC cases and noncancerous controls. Diagnostic capacity of miR-34a for BC was assessed using pooled sensitivity and specificity, DOR, and AUC of SROC. PLR and NLR were verified to estimate the miR-34a diagnostic accuracy in clinical level. The quality of the included studies was assessed by QUADAS-2. CONCLUSIONS: These findings suggest miR-34a is a promising non-invasive biomarker in diagnosing BC. Well-designed cohort studies should be implemented to warrant the diagnostic value of miR-34a in clinical purposes.

Item Type: Article
Keywords: Biomarkers, Tumor/*genetics Breast Neoplasms/*genetics Female Humans MicroRNAs/*genetics biomarker breast cancer diagnostics meta-analysis microRNA-34a
Page Range: pp. 23177-23187
Journal or Publication Title: Oncotarget
Journal Index: Pubmed
Volume: 8
Number: 14
Identification Number:
ISSN: 1949-2553
Depositing User: مهندس مهدی شریفی

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