Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Complications and Carcinogenic Effects of Mustard Gas--a Systematic Review and Meta-Analysis in Iran

(2015) Complications and Carcinogenic Effects of Mustard Gas--a Systematic Review and Meta-Analysis in Iran. Asian Pac J Cancer Prev. pp. 7567-73. ISSN 1513-7368

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BACKGROUND: Catastrophic effects of mustard gas as a chemical warfare agent have always been a major problem for those exposed to this agent. In this meta-analysis it was tried to evaluate carcinogenesis, ocular, cutaneous and respiratory complications of mustard gas exposure among Iranians who had been exposed to this agent during the Iran-Iraq war. MATERIALS AND METHODS: In this meta-analysis, the required data were collected using keywords "mustard gas", "sulfur mustard", "cancer", "neoplasm", "respiratory complications", "ocular complications" , "lung disease", "chronic complication", "eye", "skin", "cutaneous complication", "carcinogenesis" and their combination with keywords "Iran", "Iranian", "prevalence", "mortality" and their Farsi equivalent terms from the databases of SID, Iranmedex, Magiran, Pubmed, Science Direct, Google Search engine, Gray Literature and Reference of References. To determine the prevalence of each complication and perform meta-analysis, CMA: 2 (Comprehensive Meta-Analysis) software with a randomized model was used. RESULTS: Of the 542 articles found, 7 national articles, consistent with the aims of this study were selected. Meta- analysis of seven papers revealed that cancer risk, especially cancer of the respiratory system was elevated, so that the relative risk (RR) of cancer role of mustard gas was inconsistent from 2/1 to 4 in this survey. Also prevalence of delayed skin disorders due to sulfur mustard was 94.6, pulmonary complications 94.5 and ocular complications 89.9. The incidence of various cancers in victims exposed to mustard gas was 1.7 worldwide where the rate was 2.2 in Iranian victims of the Iraq-Iran war. CONCLUSIONS: Based on present study the prevalence of delayed mustard gas related cutaneous, pulmonary and ocular complications is above 90 and risk of carcinogenesis is higher in comparison to worldwide statistics. This may suggest need for long-term and persistent follow-up and rehabilitation procedures for populations exposed to this agent.

Item Type: Article
Keywords: Carcinogenesis/*drug effects Chemical Warfare Agents/*toxicity Eye/pathology Eye Neoplasms/*chemically induced/mortality Humans Iran/epidemiology Iraq Lung/pathology Lung Neoplasms/*chemically induced/mortality Mucous Membrane/drug effects/pathology Mustard Gas/*toxicity Skin/pathology Skin Neoplasms/*chemically induced/mortality
Page Range: pp. 7567-73
Journal or Publication Title: Asian Pac J Cancer Prev
Journal Index: Pubmed
Volume: 16
Number: 17
Identification Number:
ISSN: 1513-7368
Depositing User: مهندس مهدی شریفی

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