Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Prevalence of hepatitis B infection in rheumatoid arthritis patients

(2013) Prevalence of hepatitis B infection in rheumatoid arthritis patients. Pak J Biol Sci. pp. 747-50. ISSN 1028-8880 (Print) 1028-8880

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Rheumatoid arthritis is a progressive and destructive inflammatory disease of the joints. They had increased mortality depend to use of immunosuppressive drugs. Hepatitis B virus infection is also a health problem in the world. Iran is moderate prevalence endemic area for Hepatitis B virus and it is come too reduced recently by children vaccination. Aim of this study is determined prevalence and screening of Hepatitis B virus infection in rheumatoid arthritis patients. This study is a descriptive cross-sectional which all patients with rheumatic arthritis recruited to study in Tehran in 2012. Then HbsAg and HbcAb assayed for each subjects. In 268 rheumatoid arthritis patients which (82.2) were female and the average age is 46 +/- 14 years old. HbsAg and HbcAb were positive in 4 (1.49) and 9 (3.35), respectively. Only between duration of rheumatoid arthritis and HbcAb had significant association (p < 0.014). The present study highlights Rheumatoid arthritis patients treated with immunosuppressive drugs are at increased risk to reactivation of hepatitis B virus, so screening for Hepatitis B virus infection should be performed prior to immunosuppressive therapy.

Item Type: Article
Keywords: Adult Arthritis, Rheumatoid/drug therapy/*epidemiology Biomarkers/blood Chi-Square Distribution Cross-Sectional Studies Female Hepatitis B/blood/diagnosis/*epidemiology Hepatitis B Antibodies/blood Hepatitis B Surface Antigens/blood Hepatitis B virus/drug effects/immunology Humans Immunosuppressive Agents/adverse effects Iran/epidemiology Male Middle Aged Prevalence Risk Factors Virus Activation/drug effects
Page Range: pp. 747-50
Journal or Publication Title: Pak J Biol Sci
Journal Index: Pubmed
Volume: 16
Number: 15
Identification Number:
ISSN: 1028-8880 (Print) 1028-8880
Depositing User: مهندس مهدی شریفی

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