Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The role of inflammation and its related microRNAs in breast cancer: A narrative review

(2019) The role of inflammation and its related microRNAs in breast cancer: A narrative review. Journal of Cellular Physiology. pp. 19480-19493. ISSN 0021-9541

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Breast cancer is recognized as the most common type of cancer among women with a high rate of mortality all over the world. Over the past years, growing attention has been regarded to realize more about the mechanisms underlying the disease process. It is revealed that the progression of breast cancer may be strongly linked to chronic inflammation owing to the role of inflammatory factors in genetic instability and subsequent cancer predisposition. Although the association between breast cancer and inflammatory pathways has been well-defined now, only recent evidence pointed towards the inflammation-related microRNAs (miRNAs) as potential biomarkers and therapeutic targets involved in the crosstalk of multiple pathways during breast cancer development. Moreover, the practical interactions between these miRNAs and inflammatory factors are also a little characterized. In this review, we intended to describe the effects of predominant inflammatory pathways such as cytokines, phosphoinositide 3-kinase/protein kinase B, and nuclear factor kappa B in association with tumor promoting and tumor suppressing miRNAs on breast cancer progression. Providing new studies in the field of combining biomarkers for early diagnosis, prognosis, and monitoring breast cancer are very important. Notably, understanding the underlying mechanisms of miRNAs as a possible link between inflammation and tumorigenesis may offer a novel insight for combating this epidemic.

Item Type: Article
Keywords: breast cancer cytokines inflammation microRNA nuclear factor kappa B nf-kappa-b negative feedback loop necrosis-factor-alpha tumor-growth down-regulation up-regulation cells metastasis expression beta Cell Biology Physiology
Page Range: pp. 19480-19493
Journal or Publication Title: Journal of Cellular Physiology
Journal Index: ISI
Volume: 234
Number: 11
Identification Number:
ISSN: 0021-9541
Depositing User: مهندس مهدی شریفی

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