Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders

(2019) Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders. International Journal of Molecular Sciences. p. 39.

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A balanced metabolic profile is essential for normal human physiological activities. Disproportions in nutrition give rise to imbalances in metabolism that are associated with aberrant immune function and an elevated risk for inflammatory-associated disorders. Inflammation is a complex process, and numerous mediators affect inflammation-mediated disorders. The available clinical modalities do not effectively address the underlying diseases but rather relieve the symptoms. Therefore, novel targeted agents have the potential to normalize the metabolic system and, thus, provide meaningful therapy to the underlying disorder. In this connection, polyphenols, the well-known and extensively studied phytochemical moieties, were evaluated for their effective role in the restoration of metabolism via various mechanistic signaling pathways. The various flavonoids that we observed in this comprehensive review interfere with the metabolic events that induce inflammation. The mechanisms via which the polyphenols, in particular flavonoids, act provide a promising treatment option for inflammatory disorders. However, detailed clinical studies of such molecules are required to decide their clinical fate.

Item Type: Article
Keywords: flavonoids metabolic disorders inflammation oxidative stress nuclear factor-kappa B inflammatory mediators nf-kappa-b nonalcoholic fatty liver human endothelial-cells type-2 diabetes-mellitus low-density-lipoprotein tumor-necrosis-factor adhesion molecule expression cardiovascular-disease risk induced oxidative stress innate immune-system Biochemistry & Molecular Biology Chemistry
Page Range: p. 39
Journal or Publication Title: International Journal of Molecular Sciences
Journal Index: ISI
Volume: 20
Number: 19
Identification Number:
Depositing User: مهندس مهدی شریفی

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