Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

miR-9: From function to therapeutic potential in cancer

(2019) miR-9: From function to therapeutic potential in cancer. Journal of Cellular Physiology. pp. 14651-14665. ISSN 0021-9541

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Malignant neoplasms are regarded as the main cause of death around the world; hence, many research studies were conducted to further perceive molecular mechanisms, treatment, and cancer prognosis. Cancer is known as a major factor for health-related problems in the world. The main challenges associated with these diseases are prompt diagnosis, disease remission classification and treatment status forecast. Therefore, progressing in such areas by developing new and optimized methods with the help of minimally invasive biological markers such as circular microRNAs (miRNAs) can be considered important. miRNA interactions with target genes have specified their role in development, apoptosis, differentiation, and proliferation and also, confirm direct miRNA function in cancer. Different miRNAs expression levels in various types of malignant neoplasms have been observed to be associated with prognosis of various carcinomas. miR-9 seems to implement opposite practices in different tissues or under various cancer incidences by influencing different genes. Aberrant miR-9 levels have been observed in many cancer types. Therefore, we intended to investigate the precise role of miR-9 in patients with malignant neoplasms. To this end, in this study, we attempted to examine different studies to clarify the overall role of miR-9 as a prognostic marker in several human tumors. The presented data in this study can help us to find the novel therapeutic avenues for treatment of human cancers.

Item Type: Article
Keywords: cancer therapy microRNA miR-9 suppressor tumor oncogene microrna expression profiles regulates e-cadherin factor-kappa-b tumor-suppressor bladder-cancer cell-proliferation uveal melanoma prognostic value dna methylation prostate-cancer Cell Biology Physiology
Page Range: pp. 14651-14665
Journal or Publication Title: Journal of Cellular Physiology
Journal Index: ISI
Volume: 234
Number: 9
Identification Number:
ISSN: 0021-9541
Depositing User: مهندس مهدی شریفی

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