Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Plant-derived Glycosides with alpha-Glucosidase Inhibitory Activity Current Standing and Future Prospects

(2019) Plant-derived Glycosides with alpha-Glucosidase Inhibitory Activity Current Standing and Future Prospects. Endocrine Metabolic & Immune Disorders-Drug Targets. pp. 391-401. ISSN 1871-5303

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Background: The alpha-glucosidase (EC, a calcium-containing intestinal enzyme which is positioned in the cells which cover the intestinal microvilli brush border. The carbohydrates require metabolism by alpha-glucosidase before being absorbed into the small intestine, and as a result, this enzyme represents a significant drug target for the effective management of diabetes. There are few alpha-glucosidase inhibitors in the clinical practice that is challenged by several limitations. Thus, new effective and safe therapeutic agents in this class are required. In this regard, plant secondary metabolites are a very promising source to he investigated. Herein in this review, we have focused on the preclinical studies on various glycosides with in vitro alpha-glucosidase inhibitory activity. Methods: The literature available on various websites such as GoogleScholar, PubMed, Scopus. All the peer-reviewed articles were included without considering the impact factor. Results: The surveyed literature revealed marked inhibitory profile of various glycosides derived from plants, and some of them were extremely potent relatively to the standard, acarbose in preclinical trials and exhibited multiple targeted effects. Conclusion: Keeping in view the results, these glycosides are strong candidates for further, more detailed studies to ascertain their clinical potential and for effective contribution in effective management of diabetes, where multiple targets are required to address.

Item Type: Article
Keywords: Plant glycosides alpha-glucosidase inhibition SAR studies synthetic derivatives lead candidates cyanogenic glycosides flavonoid glycosides medicinal-plants beta-glucosidase resin glycosides diospyros-lotus in-vitro binding leaves elucidation transition Endocrinology & Metabolism Immunology Pharmacology & Pharmacy
Page Range: pp. 391-401
Journal or Publication Title: Endocrine Metabolic & Immune Disorders-Drug Targets
Journal Index: ISI
Volume: 19
Number: 4
Identification Number:
ISSN: 1871-5303
Depositing User: مهندس مهدی شریفی

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