Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Synthesis and characterisation of liposomal doxorubicin with loaded gold nanoparticles

(2018) Synthesis and characterisation of liposomal doxorubicin with loaded gold nanoparticles. Iet Nanobiotechnology. pp. 846-849. ISSN 1751-8741

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Developing nanostructures for cancer treatment is growing significantly. Liposomal doxorubicin is a drug that is used in the clinic and represents a lot of benefits over doxorubicin. The development of multifunctional liposomes with different cancer treatment capability enables broader applications of doxorubicin chemotherapy. Many efforts were carried to prepare more effective liposomal formulation through loading gold nanoparticles (GNPs) in the formulation. Here, GNPs with an average size of 6nm were loaded in liposomal formulation alongside doxorubicin. The hydrodynamic diameter of final formulation was 177.3 +/- 33.9nm that in comparison with liposomes without GNPs (112.5 +/- 10.3nm), GNPs-loaded liposomes showed the bigger hydrodynamic diameter. GNPs-loaded liposomes are slightly positively charged (4.4 +/- 1.1mV), while liposomes without loading the GNPs were negatively charged (-18.5 +/- 1.6mV). Doxorubicin was loaded in this formulation through active loading technique. Doxorubicin loading efficiency in gold-loaded liposomes is slightly lesser than liposomes without GNPs, but still considerably high in comparison to passive loading techniques.

Item Type: Article
Keywords: nanofabrication drugs nanomedicine gold cancer lipid bilayers drug delivery systems nanoparticles crystal growth from solution liposomal doxorubicin multifunctional liposomes doxorubicin chemotherapy active loading technique doxorubicin loading efficiency gold-loaded liposomes passive loading techniques gold nanoparticles cancer treatment liposomal formulation GNP-loaded liposomes hydrodynamic diameter in-vitro drug-delivery responsive liposomes construction antibody release systems cancer Biochemistry & Molecular Biology Science & Technology - Other Topics
Page Range: pp. 846-849
Journal or Publication Title: Iet Nanobiotechnology
Journal Index: ISI
Volume: 12
Number: 6
Identification Number:
ISSN: 1751-8741
Depositing User: مهندس مهدی شریفی

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