Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine

(2017) Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine. Nutrients. p. 22. ISSN 2072-6643

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Insulin resistance is an abnormal physiological state that occurs when insulin from pancreatic beta-cells is unable to trigger a signal transduction pathway in target organs such as the liver, muscles and adipose tissues. The loss of insulin sensitivity is generally associated with persistent hyperglycemia (diabetes), hyperinsulinemia, fatty acids and/or lipid dysregulation which are often prevalent under obesity conditions. Hence, insulin sensitizers are one class of drugs currently employed to treat diabetes and associated metabolic disorders. A number of natural products that act through multiple mechanisms have also been identified to enhance insulin sensitivity in target organs. One group of such compounds that gained interest in recent years are the dietary anthocyanins. Data from their in vitro, in vivo and clinical studies are scrutinized in this communication to show their potential health benefit through ameliorating insulin resistance. Specific mechanism of action ranging from targeting specific signal transduction receptors/enzymes to the general antioxidant and anti-inflammatory mechanisms of insulin resistance are presented.

Item Type: Article
Keywords: dietary anthocyanins insulin resistance diabetes obesity induced diabetic-rats activated protein-kinase anti-alpha-glucosidase necrosis-factor-alpha high-fat diet black soybean anthocyanins ficus-bengalensis linn peltatum torr. engl e-deficient mice in-vitro models Nutrition & Dietetics
Page Range: p. 22
Journal or Publication Title: Nutrients
Journal Index: ISI
Volume: 9
Number: 10
Identification Number:
ISSN: 2072-6643
Depositing User: مهندس مهدی شریفی

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