Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Applications of cancer stem cells in toxicology: a systematic review

(2017) Applications of cancer stem cells in toxicology: a systematic review. Minerva Biotecnologica. pp. 150-155. ISSN 1120-4826

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INTRODUCTION: Stem cells are defined as undifferentiated cells that have two distinct features, i.e., multi-lineage potential and self-renewal capacity, which means that stem cells can differentiate into a wide range of different cell type, and can self-renew to produce more stem cells with multi-lineage potential. In recent years, stem cells have been the subject of increasing scientific interest because of their utility in numerous biomedical and toxicology applications. This study aimed to assess applications of cancer stem cells in toxicological studies. EVIDENCE ACQUISITION: A search of the literature was performed through PubMed, Cochrane Library, Medline, and Science Citation Index expanded databases for articles published in English language. We performed a formal systematic review using summary measures from these studies. EVIDENCE SYNTHESIS: In total, 7 published studies were included in the final analysis. any chemical, especially at noncytotoxic concentrations, could induce intracellular signaling, which, in turn, could alter the fate of stem cells. CONCLUSIONS: The studies seem to suggest that stem cell technology represents a contribution of great impact to the field of chemical compound toxicology.

Item Type: Article
Keywords: Stem cells Toxicology Embryonic stem cells in-vitro breast-cancer generation biology differentiation communication population expression toxicity therapy Biotechnology & Applied Microbiology
Page Range: pp. 150-155
Journal or Publication Title: Minerva Biotecnologica
Journal Index: ISI
Volume: 29
Number: 3
Identification Number:
ISSN: 1120-4826
Depositing User: مهندس مهدی شریفی

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