Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Stress analysis of fracture of atherosclerotic plaques: crack propagation modeling

(2017) Stress analysis of fracture of atherosclerotic plaques: crack propagation modeling. Medical & Biological Engineering & Computing. pp. 1389-1400. ISSN 0140-0118

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Traditionally, the degree of luminal obstruction has been used to assess the vulnerability of atherosclerotic plaques. However, recent studies have revealed that other factors such as plaque morphology, material properties of lesion components and blood pressure may contribute to the fracture of atherosclerotic plaques. The aim of this study was to investigate the mechanism of fracture of atherosclerotic plaques based on the mechanical stress distribution and fatigue analysis by means of numerical simulation. Realistic models of type V plaques were reconstructed based on histological images. Finite element method was used to determine mechanical stress distribution within the plaque. Assuming that crack propagation initiated at the sites of stress concentration, crack propagation due to pulsatile blood pressure was modeled. Results showed that crack propagation considerably changed the stress field within the plaque and in some cases led to initiation of secondary cracks. The lipid pool stiffness affected the location of crack formation and the rate and direction of crack propagation. Moreover, increasing the mean or pulse pressure decreased the number of cycles to rupture. It is suggested that crack propagation analysis can lead to a better recognition of factors involved in plaque rupture and more accurate determination of vulnerable plaques.

Item Type: Article
Keywords: Atherosclerotic plaque Myocardial infarction Fracture mechanics Fatigue Finite element method fibrous cap thickness wall shear-stress vulnerable plaque blood-pressure in-vivo intravascular ultrasound circumferential stress myocardial-infarction mechanical-properties coronary plaque Computer Science Engineering Mathematical & Computational Biology Medical Informatics
Page Range: pp. 1389-1400
Journal or Publication Title: Medical & Biological Engineering & Computing
Journal Index: ISI
Volume: 55
Number: 8
Identification Number:
ISSN: 0140-0118
Depositing User: مهندس مهدی شریفی

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