Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Neuroprotective effects of astaxanthin in a rat model of spinal cord injury

(2017) Neuroprotective effects of astaxanthin in a rat model of spinal cord injury. Behavioural Brain Research. pp. 104-110. ISSN 0166-4328

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Spinal cord injury (SCI) often leads to constant neurological deficits and long-term unalterable disability. Apoptosis plays an important role in the initiation of the secondary injury cascades leading to progressive tissue damage and severely functional deficits after SCI. Although the primary mechanical destructive events cannot be reversed, a therapeutic intervention could be carried out in order to moderate the secondary injury damage several hours to weeks after injury. Astaxanthin (AST) is a strong antioxidant and anti-inflammatory agents with the potential to render anti-apoptotic and neuroprotective effects. In the current study, we examined the therapeutic potential of AST on adult rats after severe SCI contusion. Results of BBB scores showed that AST improved motor function after SCI compared to control groups. Westem blot analysis showed reduced expression of Box and Cleaved-caspase-3 proteins and increased expression of the Bcl-2 protein in response to AST treatment (p < 0.05). The histology results also showed that AST considerably preserved myelinated white matter and the number of motor neurons. This study is the first to report that AST reduces neuronal apoptosis, diminishes pathological tissue damage and improves functional recovery after SCI. The observed prominent neuroprotective effects, introduces AST as a promising therapy for SCI.

Item Type: Article
Keywords: Astaxanthin Neuroprotection Spinal cord injury Apoptosis early brain-injury oxidative stress functional recovery traumatic brain subarachnoid hemorrhage electrolytic lesion spinothalamic tract cerebral-ischemia in-vitro apoptosis Behavioral Sciences Neurosciences & Neurology
Page Range: pp. 104-110
Journal or Publication Title: Behavioural Brain Research
Journal Index: ISI
Volume: 329
Identification Number:
ISSN: 0166-4328
Depositing User: مهندس مهدی شریفی

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