Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Health effects of phloretin: from chemistry to medicine

(2017) Health effects of phloretin: from chemistry to medicine. Phytochemistry Reviews. pp. 527-533. ISSN 1568-7767

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Dihydrochalcones are a class of secondary metabolites, whose demand in biological and pharmacological applications is rapidly growing. Phloretin is one of the best known and abundant dihydrochalcone characterized by the presence of 2,6-dihydroxyacetophenone pharmacophore. It is a versatile molecule with anticancer, antiosteoclastogenic, antifungal, antiviral, anti-inflammatory, antibacterial and estrogenic activities and able to increase the fluidity of biological membranes and penetration of administered drugs. In this review we have performed a critical evaluation of available literature as far as phloretin beneficial effects and activation/block of intracellular signal cascade are of concern. In addition, we supply useful information on its chemical properties, sources and bioavailability.

Item Type: Article
Keywords: Anticancer Dihydrochalcones Phenolic compound Phloretin antioxidant activity adipocyte differentiation oxidative stress flavonoids cells apple dihydrochalcones apoptosis phlorhizin bioavailability Plant Sciences
Page Range: pp. 527-533
Journal or Publication Title: Phytochemistry Reviews
Journal Index: ISI
Volume: 16
Number: 3
Identification Number:
ISSN: 1568-7767
Depositing User: مهندس مهدی شریفی

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