Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Oleuropein and Cancer Chemoprevention: The Link is Hot

(2017) Oleuropein and Cancer Chemoprevention: The Link is Hot. Molecules. p. 13. ISSN 1420-3049

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Cancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and/or treatment of this complex disease. Oleuropein, a bioactive phenolic compound mainly present in olive oil and other natural sources, has been reported to modulate several oncogenic signalling pathways. This review presents and critically discusses the available literature about the anticancer and onco-suppressive activity of oleuropein and the underlying molecular mechanisms implicated in the anticarcinogenic and therapeutic effects. The existence of limitations and the promising perspectives of research on this phenolic compound are also critically analyzed and discussed.

Item Type: Article
Keywords: cancer chemopreventive effect oleuropein olive oil virgin olive oil olea-europaea l. ionization-mass-spectrometry phenolic-compounds natural-products capillary-electrophoresis dietary phytochemicals antioxidant activities mediterranean diet leaf extracts Biochemistry & Molecular Biology Chemistry
Page Range: p. 13
Journal or Publication Title: Molecules
Journal Index: ISI
Volume: 22
Number: 5
Identification Number:
ISSN: 1420-3049
Depositing User: مهندس مهدی شریفی

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