Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Resveratrol and Alzheimer's Disease: Mechanistic Insights

(2017) Resveratrol and Alzheimer's Disease: Mechanistic Insights. Molecular Neurobiology. pp. 2622-2635. ISSN 0893-7648

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Alzheimer's disease (AD) is the leading cause of dementia in the elderly and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of AD include extracellular senile plaques and intracellular neurofibrillary tangles. Although several mechanisms have been used to explain the underlying pathogenesis of AD, current treatment regimens remain inadequate. The neuroprotective effects of the polyphenolic stilbene resveratrol (3,5,4'-trihydroxy-trans-stilbene) have been investigated in several in vitro and in vivo models of AD. The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of AD. Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol have also been addressed.

Item Type: Article
Keywords: Alzheimer's disease Resveratrol Amyloid Neurodegeneration Neuroinflammation blood-brain-barrier trans-resveratrol oxidative stress biological evaluation red wine a-beta liquid-chromatography microglial activation cerebral-ischemia epsilon-viniferin Neurosciences & Neurology
Page Range: pp. 2622-2635
Journal or Publication Title: Molecular Neurobiology
Journal Index: ISI
Volume: 54
Number: 4
Identification Number:
ISSN: 0893-7648
Depositing User: مهندس مهدی شریفی

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