Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Applications of cardiotoxicity in breast cancer: a meta-analysis

(2017) Applications of cardiotoxicity in breast cancer: a meta-analysis. Panminerva Medica. pp. 90-96. ISSN 0031-0808

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INTRODUCTION: Breast cancer is the most common type of cancer in women. Many antineoplastic agents used to treat breast cancer have potentially cardiotoxic effects and may lead to chemotherapy induced cardiomyopathy and heart failure. We conducted a meta-analysis to clarify the applications of cardiotoxicity in breast cancer. EVIDENCE ACQUISITION: A published literature search was performed through PubMed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English. Pooled odds ratios (ORs) and 95 confidence intervals (95 CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using X-2 and I-2 statistics. We performed a formal meta-analysis using summary measures from these studies. EVIDENCE SYNTHESIS: In total, 9 published studies were included in the final analysis. The combined analysis revealed that there was nonsignificant regardless of the statistical ejection fraction (OR=0.98, 95 CI: 0.63-1.54, P=0.96) and left ventricular ejection fraction (OR=1.04; 95 CI: 0.69-1.56, P=0.85) decline method used. Additionally, the pooled OR was 0.99 (95 CI: 0.79-1.28) for the trastuzumab plus lapatinib combination, and 1.00 (95 CI: 0.88-1.13) for the trastuzumab plus pertuzumab combination. CONCLUSIONS: In this meta-analysis, there was evidence indicated that there was not a significant decrease on LVEF and EF in patients who received trastuzumab plus lapatinib and trastuzumab plus pertuzumab combination. Our study suggests that the combination of two anti-HER2 agents does not significantly increase the risk for adverse compared with anti-HER2 monotherapy in patients with adequate cardiac function prior to start of therapy.

Item Type: Article
Keywords: Cardiotoxicity Breast neoplasms Meta-analysis cardiac safety trastuzumab chemotherapy lapatinib plus radiotherapy survival therapy General & Internal Medicine
Page Range: pp. 90-96
Journal or Publication Title: Panminerva Medica
Journal Index: ISI
Volume: 59
Number: 1
Identification Number:
ISSN: 0031-0808
Depositing User: مهندس مهدی شریفی

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