Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

S100 B: A new concept in neurocritical care

(2017) S100 B: A new concept in neurocritical care. Iranian Journal of Neurology. pp. 83-89. ISSN 2008-384X

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After brain injuries, concentrations of some brain markers such as S100B protein in serum and cerebrospinal fluid (CSF) are correlated with the severity and outcome of brain damage. To perform an updated review of S100B roles in human neurocritical care domain, an electronic literature search was carried among articles published in English prior to March 2017. They were retrieved from PubMed, Scopus, EMBSCO, CINAHL, ISC and the Cochrane Library using keywords including "brain", "neurobiochemical marker", "neurocritical care", and "S100B protein". The integrative review included 48 studies until March 2017. S100B protein can be considered as a marker for blood brain barrier damage. The marker has an important role in the development and recovery of normal central nervous system (CNS) after injury. In addition to extra cerebral sources of S100B, the marker is principally built in the astroglial and Schwann cells. The neurobiochemical marker, S100B, has a pathognomonic role in the diagnosis of a broad spectrum of brain damage including traumatic brain injury (TBI), brain tumor, and stroke. Moreover, a potential predicting role for the neurobiochemical marker has been presumed in the efficiency of brain damage treatment and prognosis. However further animal and human studies are required before widespread routine clinical introduction of S100 protein.

Item Type: Article
Keywords: Biologic Marker Surrogate Marker Serum Marker S100B Protein Progressive Patient Care Neurosciences & Neurology
Page Range: pp. 83-89
Journal or Publication Title: Iranian Journal of Neurology
Journal Index: ISI
Volume: 16
Number: 2
ISSN: 2008-384X
Depositing User: مهندس مهدی شریفی

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