Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Daidzein and its Effects on Brain

(2017) Daidzein and its Effects on Brain. Current Medicinal Chemistry. pp. 365-375. ISSN 0929-8673

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Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which has been reported to affect various neurobiological regulatory mechanisms such as behavior, cognition, growth, development and reproduction. These effects are mainly elicited through the interaction of daidzein with different signaling molecules and receptors, thereby offering neuroprotection. In addition, daidzein has also been reported to possess activities against various neuropathological conditions mainly by its interaction with the cerebrovascular system. This review focuses on providing a comprehensive account on the bioavailability and metabolism of daidzein in vivo, and discusses its activities and mechanisms of action in detail, in both physiological and pathological conditions. In addition, the effects of daidzein on other disorders have also been examined briefly in this article.

Item Type: Article
Keywords: Daidzein genistein hormones neuroprotection cellular pathways focal cerebral-ischemia estrogen-receptor-beta tandem mass-spectrometry soy isoflavone daidzein pueraria-lobata roots messenger-rna neuronal apoptosis female rats liquid-chromatography soybean isoflavones Biochemistry & Molecular Biology Pharmacology & Pharmacy
Page Range: pp. 365-375
Journal or Publication Title: Current Medicinal Chemistry
Journal Index: ISI
Volume: 24
Number: 4
Identification Number:
ISSN: 0929-8673
Depositing User: مهندس مهدی شریفی

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