Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Potential Utility of N-acetylcysteine for Treating Mustard Lung

(2017) Potential Utility of N-acetylcysteine for Treating Mustard Lung. Critical Reviews in Eukaryotic Gene Expression. pp. 247-266. ISSN 1045-4403

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More than a century after the introduction of sulfur mustard (SM), as a chemical warfare agent, it has affected thousands of military and civilians on several occasions. The most notable toxic effects of this easily produced chemical, are lung damage ranges from necrotic, hemorrhagic, and infectious acute-lung injury to chronic conditions (i.e., mustard lung). While there is no definite treatment for individuals exposed to sulfur mustard, corticosteroids, mucolytics, bronchodilators, antibiotics, immunosuppressive medicines, and magnesium are being used to help victims. In the pathophysiology of SM-induced lung conditions, oxidative stress and inflammation play undeniable roles; thus, N-acetyl-L-cysteine (NAC) has been used as a treatment. In this narrative review article, we discuss the mechanisms involved in SM-induced lung damage along with the properties of NAC that can help patients recover from these deleterious effects.

Item Type: Article
Keywords: N-actylcysteine sulfur mustard chemical injury lung obstructive pulmonary-disease 2-chloroethyl ethyl sulfide acetyl-l-cysteine gas-exposed patients quality-of-life induced cutaneous complications bronchoalveolar lavage fluid randomized controlled-trial bronchial epithelial-cells nitric-oxide synthase Biotechnology & Applied Microbiology Genetics & Heredity
Page Range: pp. 247-266
Journal or Publication Title: Critical Reviews in Eukaryotic Gene Expression
Journal Index: ISI
Volume: 27
Number: 3
Identification Number:
ISSN: 1045-4403
Depositing User: مهندس مهدی شریفی

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