Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin

(2017) A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin. Current Drug Targets. pp. 1529-1536. ISSN 1389-4501

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Background: The plant milk thistle and silymarin has been traditionally used as a natural remedy for the treatment of various ailments including neurological disorders such as Alzheimer's and Parkinson's disease and cerebral ischemia for over 2000 years. Objective: In this article we review the neuroprotective effects of silymarin against various neurological dysfunctions. Results: The neuroprotective effects conferred by silymarin include modulation of various antioxidant mechanisms, and several kinases involved in cell signaling pathways, inhibition of the inflammatory response generated during neurodegeneration, neurotropic effects, regulation of neurotransmitters and inhibition of apoptosis. The ease of availability, comparative low cost and safety profile provide additional advantages for the use of this compound as a potent drug with immense clinical benefit. However, there is a growing need for improvements in the bioavailability of silymarin and related products, and more consistent and reliable human trials are required to accurately validate the neuroprotective efficacy of this natural compound. Conclusion: The promising outcomes of the studies mentioned in this review provide renewed insight into the clinical relevance of silymarin in a variety of neurodegenerative disorders where neuroinflammation and oxidative stress are pathologically relevant to disease progression.

Item Type: Article
Keywords: Alzhemer's disease neurodegeneration Parkinson's disease silymarin neuroprotective effects oxidative stress nf-kappa-b focal cerebral-ischemia oxidative stress milk thistle neurodegenerative diseases silybum-marianum silibinin brain antioxidant impairment Pharmacology & Pharmacy
Page Range: pp. 1529-1536
Journal or Publication Title: Current Drug Targets
Journal Index: ISI
Volume: 18
Number: 13
Identification Number:
ISSN: 1389-4501
Depositing User: مهندس مهدی شریفی

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