Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Distribution of high-level mupirocin resistance among clinical MRSA

(2017) Distribution of high-level mupirocin resistance among clinical MRSA. Journal of Chemotherapy. pp. 215-219. ISSN 1120-009X

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Mupirocin is a topical antibiotic for methicillin-resistant Staphylococcus aureus (MRSA) decolonization in hospital settings and nursing homes and is used as a highly effective antibiotic against MRSA. In this study, we aimed to evaluate the frequency of high-level mupirocin-resistant (HLMR) strains among the MRSA subtypes. A total of 188 clinical MRSA isolates were collected from 2011 to 2014, and their susceptibility to antimicrobial agents and vancomycin resistance was evaluated using disc diffusion method and micro-dilution method, respectively. Furthermore, the presence of mecA, SSCmec, mupA and mupB was assessed by PCR. All isolates were multi-drug resistant (MDR) but 2 strains (1.06) were resistant to mupirocin. Minimum inhibitory concentration (MIC) of vancomycin for 8 strains (4.7) was higher than 2 mu g/ml. Of 188 isolates, 188 (100), 64 (34.04), 8 (4.3), 150 (79.8), 26 (13.8), 2 (1.06) and 2 (1.06) isolates possessed mecA, SCCmec types I, II, III, IV, mupA and mupB genes, respectively. Our data showed that despite infection control policy enforced by health care committee, the rate of mupirocin resistance among MRSA strains is continuously rising.

Item Type: Article
Keywords: Staphylococcus aureus MRSA Mupirocin Multi-drug resistant staphylococcus-aureus strains multiplex pcr assay susceptibility patterns clonal dissemination mupa gene mec prevalence iran identification chlorhexidine Oncology Infectious Diseases Pathology Pharmacology & Pharmacy
Page Range: pp. 215-219
Journal or Publication Title: Journal of Chemotherapy
Journal Index: ISI
Volume: 29
Number: 4
Identification Number:
ISSN: 1120-009X
Depositing User: مهندس مهدی شریفی

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