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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Melatonin and Respiratory Diseases: A Review

(2017) Melatonin and Respiratory Diseases: A Review. Current Topics in Medicinal Chemistry. pp. 467-488. ISSN 1568-0266

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Melatonin is an indoleamine with potent multifunctional biological and pharmacological effects, both receptor dependent and receptor-independent effects, including antioxidant, anticancer, antitumor, anti-inflammatory, anti-aging, anti-diabetic, antiviral, neuroprotective activities. Melatonin mitigates tissue injury via modification of abnormalities in redox status and other biochemical markers. At the molecular level, the biological and pharmacological activities of melatonin are attributed to the inhibition of nuclear factor-.appa beta (NF-kappa beta), c-Fos over expression and down-regulation of matrix metalloproteinases-3 (MMP-3), which are regulators of pro-inflammatory and pro-fibrotic cytokines. There are numerous scientific reports on the therapeutic potential of melatonin in treatment of asthma, respiratory diseases for infections, chronic obstructive pulmonary disease, lung cancer, pleural cavity diseases, as well as vascular pulmonary disease. In the present communication, we systematically review the therapeutic potential of melatonin in the treatment of respiratory diseases along with its molecular mechanism of actions.

Item Type: Article
Keywords: Anti-inflammatory Antioxidant Lung disease Melatonin Pulmonary disease Respiratory disorders obstructive pulmonary-disease cell lung-cancer pineal hormone melatonin induced oxidative stress breast-cancer in-vitro glutathione-peroxidase cigarette-smoking circadian-rhythms induced apoptosis Pharmacology & Pharmacy
Page Range: pp. 467-488
Journal or Publication Title: Current Topics in Medicinal Chemistry
Journal Index: ISI
Volume: 17
Number: 4
Identification Number:
ISSN: 1568-0266
Depositing User: مهندس مهدی شریفی

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