Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Development of a novel 68 Ga-dextran carboxylate derivative for blood pool imaging

(2019) Development of a novel 68 Ga-dextran carboxylate derivative for blood pool imaging. Radiochimica Acta. pp. 233-242. ISSN 00338230 (ISSN)

Full text not available from this repository.

Official URL:


To develop a possible PET blood pool imaging agent, a series 68 Ga-dextran carboxylate derivatives were prepared. Dextran carboxylates with different degree of oxidations (DO) were prepared through stepwise dextran oxidation using NaIO 4 and CH 3 COOOH. The products were characterized by FT-IR and GPC, followed by solubility and toxicity tests on Hella cells (viability=98.6, 97.4 and 95.6 for 3 dextran carboxylates with DOs: 8.3, 24.6 and 39.8, respectively. The products were labeled with 68 Ga (radiochemical purity>98; ITLC) followed by stability tests in final solution as well as in presence of cycteine and human serum. Two stable tracers (DOs; 24.6 and 39.8) were adminstered intravenously into wild type rat tail vein separately demonstrating suitable retention in circulation as expected from blood pool imaging agents. Liver and spleen also contained activities. The major excretion was through urinary pathway esp. for derivative with DO. 39.8. Unlike 68 Ga-dextran, lungs showed lower uptake. The dextran carboxylate with the highest 39.8 showed the best characteristics for a blood pool agent, though more studies including PET imaging in larger mammals are required. © 2019 Walter de Gruyter GmbH, Berlin/Boston.

Item Type: Article
Keywords: biodistribution blood pool agents dextran carboxylate Gallium-68 radiolabeling toxicity
Page Range: pp. 233-242
Journal or Publication Title: Radiochimica Acta
Journal Index: Scopus
Volume: 107
Number: 3
Identification Number:
ISSN: 00338230 (ISSN)
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item