Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas

(2016) Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas. Journal of the Neurological Sciences. pp. 249-252. ISSN 0022-510X

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Background: Gliomas are among the most frequent adult primary brain tumors. Recent studies have shown that there are novel opportunities for developing therapeutics by targeting the differentiation and self-renewal features of glioma. Objective: The aim of this study was to evaluate the expression levels of USP2a an Nrf2 in patients with glioma and their association with prognosis of gliomas that was detected with immunohistochemical staining. Methods: In this study, 40 patient's tissue samples with primary gliomas were collected between January 2009 and December 2013. MRI of patients was done before and within 24 h after surgery. USP2a and Nrf2 expression levels were examined by immunohistochemistry. Data were analyzed using the SPSS 16.0, X-2 test, log-rank test and Kaplan-Meier method. Results: lmmunohistochemistry indicated that USP2a expression was increased in glioma cells than normal brain tissues. The increased USP2a staining was markedly correlated with advanced tumor grade (P = 0.02) and age (P = 0.016). Our result showed that Nrf2 expression was significantly higher in glioma cells as compared to normal brain tissues. The high expression level of Nrf2 was markedly linked to age (P = 0.007), and tumor grade (P = 0.03). Kaplan-Meier survival and log-rank analysis indicated that patients with low expression of USP2a had longer overall survival than those with high levels (log-rank test P < 0.001). Moreover, patients with high Nrf2 expression had shorter overall survival than those with low levels (log-rank test P < 0.001). In the univariate analysis, the high expression of Nrf2 and USP2a (P = 0.004; P = 0.006), age (P = 0.025), and tumor grade (P = 0.001) were correlated with poor survival. Multivariate Cox proportional hazards model indicated that, high Nrf2 and USP2a staining (P = 0.001; P = 0.003), advanced tumor grade (P = 0.01) and age (P = 0.033) were independent predictor of overall survival. Conclusion: In summary, the result of this study showed USP2a and Nrf2 may be as prognostic marker in patients with gliomas. (C) 2016 Published by Elsevier B.V.

Item Type: Article
Keywords: Gliomas USP2a Nrf2 immunohistochemistry Prognosis Patient Prognosis prostate-cancer poor-prognosis brain-tumors lung-cancer stem-cells glioblastoma expression therapy adults grade Neurosciences & Neurology
Page Range: pp. 249-252
Journal or Publication Title: Journal of the Neurological Sciences
Journal Index: ISI
Volume: 363
Identification Number:
ISSN: 0022-510X
Depositing User: مهندس مهدی شریفی

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