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Baqiyatallah University of Medical Sciences

Cytoprotective mechanism of action of curcumin against cataract

(2016) Cytoprotective mechanism of action of curcumin against cataract. Pharmacological Reports. pp. 561-569. ISSN 1734-1140

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This review discusses the relationship between oxidative stress and cataract formation, molecular mechanism of curcumin action and potential benefits of treatment with the antioxidant curcumin. The first section deals with curcumin and endogenous antioxidants. The second section focuses on the action of curcumin on lipid peroxidation. Calcium homeostasis and curcumin will be discussed in the third section. The fourth section discusses the role of crystallin proteins that are responsible for maintaining lens transparency and the role of curcumin in regulating crystallin expression. The interaction of curcumin with transcription factors will be dealt in the fifth section. The final section will focus on the effect of curcumin on aldose reductase, which is associated with hyperglycemia and cataract. One of the strongest antioxidants is curcumin which has been shown to be very effective against cataract. This compound is better than other antioxidants in preventing cataract but its limited bioavailability can be addressed by employing nanotechnology. (C) 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.

Item Type: Article
Keywords: Cataract Curcumin Lens Oxidative stress Anticataract nf-kappa-b endothelial growth-factor induced diabetic-rat age-related cataract breast-cancer cells see vol. 102 superoxide-dismutase alpha-crystallin lipid-peroxidation dietary curcumin Pharmacology & Pharmacy
Page Range: pp. 561-569
Journal or Publication Title: Pharmacological Reports
Journal Index: ISI
Volume: 68
Number: 3
Identification Number:
ISSN: 1734-1140
Depositing User: مهندس مهدی شریفی

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