Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Diagnostic value of CD117 in differential diagnosis of acute leukemias

(2014) Diagnostic value of CD117 in differential diagnosis of acute leukemias. Tumor Biology. pp. 6763-6768. ISSN 1010-4283

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C-kit receptor (CD117) and its ligand, stem cell factor, play a key role in normal hematopoiesis. It has been demonstrated that its expression extremely increases in leukemias with myeloid commitment. We analyzed findings on CD117 expression together with other myeloid related markers in 203 de novo acute leukemias, referred to Iranian immunophenotyping centers: Iranian Blood Transfusion Organization (IBTO) and Baghiatallah Hospital (BH). All cases were characterized based on the French American British cooperative group (FAB) and European Group for Immunological Classification of Leukemias (EGIL). The cases comprised of 111 acute myeloblastic leukemia (AML), 86 acute lymphoblastic leukemia (ALL), and 6 acute undifferentiated leukemia (AUL). CD117 was positive in 75 of AML and 50 of AUL, whereas none of the ALL cases was positive for this marker. Although CD117 was positive in 100 of M5a cases, no M5b positive was found (p = 0.036). The calculated specificity for myeloid involvement was 100 for CD117 and CD33, and 98 for CD13 and CD15 (p < 0.001). The calculated sensitivity for myeloid involvement was 83, 76, 64, and 41 for CD13, CD117, CD33, and CD15, respectively (p < 0.001). We concluded that CD117 expression is a specific and rather sensitive marker for differential diagnosis between AML and ALL, and except for M5 subtypes, it fails to determine FAB subtypes; lack of expression in M5 can identify M5b. Therefore, it should be included in the routine primary panel for diagnosis of acute leukemias.

Item Type: Article
Keywords: Acute Leukemia Immunophenotyping CD117 AML ALL kit receptor cd117 acute myeloid-leukemia c-kit hematological malignancies lymphoblastic-leukemia flow-cytometry expression specificity mutation cells Oncology
Page Range: pp. 6763-6768
Journal or Publication Title: Tumor Biology
Journal Index: ISI
Volume: 35
Number: 7
Identification Number:
ISSN: 1010-4283
Depositing User: مهندس مهدی شریفی

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