Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Recombinant human interferon gamma (Gamma Immunex) in treatment of atopic dermatitis

(2012) Recombinant human interferon gamma (Gamma Immunex) in treatment of atopic dermatitis. Clinical and Experimental Medicine. pp. 241-245. ISSN 1591-8890

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Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study evaluated the effect of recombinant human interferon gamma (rIFN-gamma: Gamma Immunex, Exir Pharmaceutical Company, Iran) on severity of AD (SCORAD), dermatology life quality index (DLQI) as well as serum levels of IL-4, IgE and IL-6 in AD patients. Twenty AD patients were entered in to a study in Baqiyatallah outpatient clinics and received rIFN-gamma (50 mu g/m(2) body area, 3 times per week, subcutaneously) for 1 month. SCORAD and DLQI were assessed at beginning and end of the treatment period. IL-4, IL-6 and IgE were measured in blood samples before and after 1 month treatment with rIFN-gamma. DLQI mean value before treatment was 20.80 +/- A 3.95, which decreased to 8.20 +/- A 2.14 after treatment (P < 0.001). SCORAD-A (percentile of the body surface involved in AD), SCORAD-B (the severity of clinical features) and SCORAD-C (patients' scaling of itching and somnolence) significantly decreased after treatment (P < 0.001, P < 0.001 and P < 0.01). Total SCORAD at the end of treatment period was less than basal value (27.83 +/- A 8.48 vs. 70.04 +/- A 8.48; P < 0.001). Treatment with rIFN-gamma decreased serum levels of IL-4 and IL-6 (P < 0.05), but IgE remained unchanged. Results suggested the controlling effect of rIFN-gamma treatment on clinical symptoms of AD, which involves suppression of IL-4 but not IgE production.

Item Type: Article
Keywords: Atopic dermatitis Gamma interferon Quality of life Interleukin party diagnostic-criteria ifn-gamma ige production growth-factor nc/nga mice serum ige therapy interleukin-4 activation expression Research & Experimental Medicine
Page Range: pp. 241-245
Journal or Publication Title: Clinical and Experimental Medicine
Journal Index: ISI
Volume: 12
Number: 4
Identification Number:
ISSN: 1591-8890
Depositing User: مهندس مهدی شریفی

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