Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Incidence of Malignancy after Living Kidney Transplantation: A Multicenter Study from Iran

(2012) Incidence of Malignancy after Living Kidney Transplantation: A Multicenter Study from Iran. Journal of Cancer. pp. 246-256. ISSN 1837-9664

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Malignancy is a common complication after renal transplantation. However, limited data are available on post-transplant malignancy in living kidney transplantation. Therefore, we made a plan to evaluate the incidence and types of malignancies, association with the main risk factors and patient survival in a large population of living kidney transplantation. We conducted a large retrospective multicenter study on 12525 renal recipients, accounting for up to 59 of all kidney transplantation in Iran during 22 years follow up period. All information was collected from observation of individual notes or computerized records for transplant patients. Two hundred and sixty-six biopsy-proven malignancies were collected from 16 Transplant Centers in Iran; 26 different type of malignancy categorized in 5 groups were detected. The mean age of patients was 46.2 +/- 12.9 years, mean age at tumor diagnosis was 50.8 +/- 13.2 years and average time between transplantation and detection of malignancy was 50.0 +/- 48.4 months. Overall tumor incidence in recipients was 2. Kaposis' sarcoma was the most common type of tumor. The overall mean survival time was 117.1 months (95 CI: 104.9-129.3). In multivariate analysis, the only independent risk factor associated with mortality was type of malignancy. This study revealed the lowest malignancy incidence in living unrelated kidney transplantation.

Item Type: Article
Keywords: malignancy kidney transplantation incidence renal-transplantation patient survival cancer incidence risk-factors skin-cancer recipients experience immunosuppression azathioprine rapamycin Oncology
Page Range: pp. 246-256
Journal or Publication Title: Journal of Cancer
Journal Index: ISI
Volume: 3
Identification Number:
ISSN: 1837-9664
Depositing User: مهندس مهدی شریفی

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