Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Neonatal thyroid status in an area of iodine sufficiency

(2011) Neonatal thyroid status in an area of iodine sufficiency. Journal of Endocrinological Investigation. pp. 197-200. ISSN 0391-4097

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Background: Iodine deficiency constitutes a public health problem in many countries worldwide. Fetal neurodevelopment is affected by maternal iodine intake. The aim of present study was to assess urinary iodine excretion (UIE) in the 3 trimesters of pregnancy and evaluate its association with newborn thyroid function in Tehran, an area of iodine sufficiency. Methods: Based on median urinary iodine in 3 trimesters, 138 pregnant women were divided into 2 groups with UIE<150 (group I) and UlE150 mu g/l (group II). Cord blood samples of their newborns were evaluated for serum concentrations of TSH, T-3, T-4, free T-4 (FT4), and thyroglobolin. Quartiles of UIE were also determined. Correlations between mothers' UIE and newborns' thyroid function in both groups were investigated. Results: Fifty-two pregnant women (38) had median UIE<150 mu g/l and 86 had (62) UIE >= 150 mu g/l. Median UIE in groups land II in the 1(st), 2(nd), and 3(rd) trimesters were 125 and 212 mu g/l 97 and 213 mu g/l, 93 and 227 mu g/l, respectively. No significant difference was seen in thyroid function of newborns in the 2 groups. Mean concentrations of T-4, T-3, FT4, and TSH of newborn did not show significant difference in median UIE of mothers in various quartiles. Conclusion: This study shows that newborns, irrespective of mothers' UIE, in an area with a sustained iodine supplementation program, may not be at risk of alterations in thyroid functions. (J. Endocrinol. Invest. 34: 197-200, 2011) (C) 2011, Editrice Kurtis

Item Type: Article
Keywords: Iodine sufficiency neonatal thyroid hormone levels deficiency newborns indicators pregnancy women tsh Endocrinology & Metabolism
Page Range: pp. 197-200
Journal or Publication Title: Journal of Endocrinological Investigation
Journal Index: ISI
Volume: 34
Number: 3
Identification Number:
ISSN: 0391-4097
Depositing User: مهندس مهدی شریفی

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