Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effects of Low Intensity Pulsed Ultrasound on Healing of Denervated Tibial Fracture in the Rabbit

(2011) Effects of Low Intensity Pulsed Ultrasound on Healing of Denervated Tibial Fracture in the Rabbit. Iranian Red Crescent Medical Journal. pp. 34-41. ISSN 2074-1804

[img] Text
Effects of low intensity pulsed ultrasound on healing of denervated tibial fracture in the rabbit.pdf

Download (502kB)

Official URL:


Background: Low intensity pulsed ultrasound (LIPUS) has been shown in healing of fractures. This study investigates the effect of LIPUS as a fracture-healing adjunct on the denervated tibial fractures in rabbit model. Methods: Twenty four male Dutch rabbits were randomly divided into four groups including two control and two ultrasound-treated (US-treated) groups. A standardized mid-tibial osteotomy was performed in the right tibia. Ipsilateral sciatic nerve was cut two centimeter above the right knee. After three days, the rabbits of US-treated groups received the therapeutic dose (100 mW/cm(2)) of ultrasound for 15 minutes per day until the 6(th) and 8(th) week and the control groups did not receive any treatment. The rabbits were sacrificed at weeks 6(th) and 8(th) post surgery and the external fixator and tibia were carefully removed. Radiographs were taken by lateral and anteroposterior views. Mechanical testing of rabbit's tibiae was used. The specimens were taken from callus of fracture for histomorphometric study of trabecula in the fractured area. Immunohistochemical staining for ki67 was used to evaluate cellular proliferation. Results: Radiographs showed the callus was visible indicating the ossification of the callus tissue without any significant difference between US- treated and control groups. Biomechanical, histomorphic and immunohistochemical evaluations had no significant difference between control and US-treated groups after 6 and 8 weeks postoperation. Conclusion: These finding suggest that ultrasound therapy with features which applied in this study had no significant effect on denervated tibial fracture repair in rabbits.

Item Type: Article
Keywords: Ultrasound Fracture Bone healing Nerve lesion Rabbit aggrecan gene-expression therapeutic ultrasound rat increases model acceleration nonunions strength General & Internal Medicine
Page Range: pp. 34-41
Journal or Publication Title: Iranian Red Crescent Medical Journal
Journal Index: ISI
Volume: 13
Number: 1
ISSN: 2074-1804
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item