Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Antimicrobial susceptibility of Helicobacter pylori strains isolated from patients in Shiraz, Southern Iran

(2010) Antimicrobial susceptibility of Helicobacter pylori strains isolated from patients in Shiraz, Southern Iran. World Journal of Gastroenterology. pp. 5746-5751. ISSN 1007-9327

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AIM: To improve our understanding of Iranian regional variation in Helicobacter pylori (H. pylon) antibiotic resistance rates to find the best antibiotic therapy for eradication of H. pylori infections. METHODS: A total of 266 patients undergoing endoscopy in Shiraz, Southern Iran, were included in this study. H. pylori strains were isolated from antral biopsies by culture and confirmed by the rapid urease-test and gram staining. Antibiotic susceptibility of H. pylon isolates was determined by E-test. RESULTS: A total of 121 H. pylori strains were isolated, 50 from male and 71 from female patients. Data showed that 44 (n = 53), 20 (n = 24), 5 (n = 6), and 3 (n = 4) of all strains were resistant to the antibiotics metronidazole, amoxicillin, clarithromycin, and tetracycline, respectively. When the antibiotics were considered together we found 11 sensitivity patterns for the strains. Resistance to metronidazole was significantly higher in female than in male patients (P < 0.05). In about 71 of the metronidazole-resistant isolates, the minimum inhibitory concentrations (MICs) exceeded 256 mu g/mL. CONCLUSION: We found a moderate rate of primary resistance to metronidazole. However, a high MIC (> 256 mg/L) which was found in 71 of the isolates is considerable. In the case of amoxicillin, an increased resistance rate of 20 is worrying. Resistance to clarithromycin and tetracycline is also emerging among the H. pylori strains in our region. (C) 2010 Baishideng. All rights reserved.

Item Type: Article
Keywords: Gastric disorders Helicobacter pylori Iran Sensitivity Treatment antibiotic-resistance clarithromycin resistance agar dilution metronidazole susceptibility disk-diffusion ribosomal-rna in-vitro prevalence mutations eradication Gastroenterology & Hepatology
Page Range: pp. 5746-5751
Journal or Publication Title: World Journal of Gastroenterology
Journal Index: ISI
Volume: 16
Number: 45
Identification Number:
ISSN: 1007-9327
Depositing User: مهندس مهدی شریفی

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