Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Hepatitis B Virus Infection in Iran: A Systematic Review

(2008) Hepatitis B Virus Infection in Iran: A Systematic Review. Hepatitis Monthly. pp. 281-294. ISSN 1735-143X

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Background and Aims:Hepatitis B virus (HBV) infection is a worldwide problem. It is estimated that 400 million people are suffering from this infection. We conducted a systematic review to put all evidence on HBV infection in I.R. Iran and to make an accurate estimate of HBV infection prevalence in Iran for further planning to control the infection. Study Design: Meta-analysis and survey data analysis of all national and international papers, theses, congresses, reports, Iranian medical universities projects, research centers, reports of Deputy for Health affairs (published or unpublished). Setting & Population: Iranian general population with positive HBsAg in blood samples Selection Criteria for Studies:All descriptive/analytical cross-sectional studies/surveys from April 2001 to March 2007 that have sufficiently declared objectives, proper sampling method with identical and valid measurement instruments for all study subjects and proper analysis methods regarding sampling design and demographic adjustments Outcomes: Presence of positive HBsAg in blood samples of study samples Results: Fourteen studies met the inclusion criteria. They were from 7 (out of 30) provinces in which about 40 percent of the country population live. These provinces (HBsAg positive prevalence) were Golestan (6.3), Tehran (2.2), East Azarbaijan (1.3), Hamedan (2.3), Isfahan (1.3), Kermanshah (1.3) and Hormozgan (2.4). The HBV infection prevalence in Iran is estimated to be 2.14 percent (95CI: 1.92-2.35), in men and women 2.55 percent (95CI: 2.25-2.85) and 2.03 percent (95CI: 1.6-2.46 percent) respectively. Conclusions: About 1.5 million people in Iran are living with HBV infection (mild to moderate prevalence according to WHO classification) and it is assumed that 15 to 40 of them are at risk of developing cirrhosis and/or hepatocellular carcinoma (HCC) without intervention. The prevalence of HBV infection has been reported higher in more recent studies compared to the study in 2000-2001.

Item Type: Article
Keywords: Hepatitis B Iran Systematic Review hemodialysis-patients risk-factors blood-donors hemophilic patients anti-hcv hbs ag prevalence seroprevalence children hiv Gastroenterology & Hepatology
Page Range: pp. 281-294
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 8
Number: 4
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی

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