Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Immunogenicity of pneumococcal vaccination in renal transplant recipients and hemodialysis patients: A comparative controlled trial

(2008) Immunogenicity of pneumococcal vaccination in renal transplant recipients and hemodialysis patients: A comparative controlled trial. Annals of Transplantation. pp. 43-47. ISSN 1425-9524

Full text not available from this repository.

Official URL:


Background: The objectives of this study were: to assess and compare the antibody responses of renal allograft recipients and dialysis patients to pneumococcal vaccination. Material/Methods: 14 stable dialysis patients as well as 37 kidney transplant recipients were eligible for inclusion in this trial. Participated patients receive a single 0.5-mL of 23-valent vaccine Pneumovax (R) administered intramuscularly in the upper extremities. The efficacy of vaccination was evaluated by measuring the antibody response to the whole vaccine. Sera were obtained prior to vaccination and 4 weeks, 6 months and 1 year after the vaccination. Results: Prior to vaccination, mean IgG and IgG2 titers were equivalent in Dx and KTx patients (p>0.1 in both). Four weeks after vaccination, 49 out of 51 participated patients (96) represented an increase in their anti pneumococcal IgG levels (mean 99 +/- 66) compared to 48 out of 51 (94) for month 6 (mean 90 +/- 59), and 38 out of 45 (85) for the first year after vaccination (mean 73 +/- 69). KTx patients kept significantly more serum IgG2 levels at months 6 and 12 after vaccination (p=0.001, p=0.03, respectively; Table 1). Mean IgG values for month 6 was 9 +/- 41 units lesser than month 1 post vaccination serum IgG levels. Conclusions: We found that patients with renal failure on hemodialysis and kidney transplantation well respond to immunization by anti pneumococcal vaccination. But, they rapidly loss their serum antibody levels during the one year after vaccination. Specifying protective levels for serum IgG and IgG2 levels in these patients would help us to more precisely follow these patients and to consider a revaccination when they failed to save the protective serum antibody level.

Item Type: Article
Keywords: pneumococcal vaccination immunogenicity renal transplant patients hemodialysis influenza vaccination antibody-response immune-response immunization azathioprine infections vaccines adults Surgery Transplantation
Page Range: pp. 43-47
Journal or Publication Title: Annals of Transplantation
Journal Index: ISI
Volume: 13
Number: 3
ISSN: 1425-9524
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item