Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Cyclosporine in treatment of membranoproliferative glomerulonephritis

(2008) Cyclosporine in treatment of membranoproliferative glomerulonephritis. Archives of Iranian Medicine. pp. 26-29. ISSN 1029-2977

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Background: Therapeutic approach to patients with idiopathic membranoproliferative glomerulonephritis is still controversial. Because it is more common in developing countries, the studies about it are limited. Methods: We used cyclosporine to treat 18 patients with membranoproliferative glomerulonephritis who were resistant to other treatment protocols such as using aspirin, dipyridamole, or steroids. All patients were treated with cyclosporine plus low-dose prednisone and were followed for an average 108 weeks. Results: Partial or complete remission of proteinuria occurred in 94 of the patients (P<0.01). Relapse occurred in one (14.2) of remitters after discontinuation of the drug. But the remainder stayed in remission to the end of the observation period. There was a 50 decrease in the baseline creatinine clearance in one patient (5.5). Conclusion: These results suggest that cyclosporine may be an effective therapeutic agent in the treatment of resistant idiopathic membranoproliferative glomerulonephritis. Although, the response is appeared later than other types of glomerulonephritis, but a long-term decrease in proteinuria and preservation of filtration function were observed in a significant proportion of the treated patients.

Item Type: Article
Keywords: cyclosporine A end-stage renal disease membranoproliferative glomerulonephritis resistant nephrotic syndrome mesangiocapillary glomerulonephritis therapy disease trial General & Internal Medicine
Page Range: pp. 26-29
Journal or Publication Title: Archives of Iranian Medicine
Journal Index: ISI
Volume: 11
Number: 1
ISSN: 1029-2977
Depositing User: مهندس مهدی شریفی

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