Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Comparison of topical capsaicin and betamethasone in the treatment of chronic skin lesions due to sulfur mustard exposure

(2008) Comparison of topical capsaicin and betamethasone in the treatment of chronic skin lesions due to sulfur mustard exposure. Cutaneous and Ocular Toxicology. pp. 203-211. ISSN 1556-9527

Full text not available from this repository.

Official URL:


Chronic pruritic skin lesions art considered to be one of the late complications of sulfur mustard exposure. The purpose of this study was to compare the efficacy of topical capsaicin with that of betamethasone in the treatment of these lesions. In this investigator-blinded, randomized clinical trial. patients applied capsaicin cream 0.025 (n = 32) or betamethasone cream 0.1 (n = 32) 2 times a day for 6 weeks. Efficacy was based on a dermatologist assessment. The severity of the pruritus was assessed by pruritic score questionnaire and a visual analog scale before and after treatment. All patients complained of pruritus. Both groups showed a significant decrease in pruritus, scaling, and skin dryness (p < 0.05), but burning sensation was not improved significantly in the capsaicin group. The mean (+/- standard deviation SD) baseline pruritic scores in the capsaicin and betamethasone groups were 29.4 (13.1) and 33.6 (7.2), respectively (p = 0.1). The mean (SD) pruritus score change from baseline to after the treatment was significantly higher (p < 0.001) in the betamethasone group than in tire capsaicin group, 12.7 (6.4) vs. 6.9 (5.6). Fourteen (35%) patients in the capsaicin group reported a burning sensation and intolerable, odor, but these effects were not serious enough to necessitate discontinuing the treatment. Topical capsaicin cream 0.025% was much less well tolerated than betamethasone and inferior to betamethasone in reducing chronic skin lesions and symptoms from sulfur mustard exposure.

Item Type: Article
Keywords: sulfur mustard chronic skin lesions pruritus capsaicin betamethasone normal human keratinocytes chemical warfare agents iranian veterans late complications cytokine release gas manifestations histamine pruritus therapy Ophthalmology Toxicology
Page Range: pp. 203-211
Journal or Publication Title: Cutaneous and Ocular Toxicology
Journal Index: ISI
Volume: 27
Number: 3
Identification Number:
ISSN: 1556-9527
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item