Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Outcome of living kidney transplant: Pediatric in comparison to adults

(2007) Outcome of living kidney transplant: Pediatric in comparison to adults. Transplantation Proceedings. pp. 1088-1090. ISSN 0041-1345

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Background. Renal transplantation is the most optimal way to manage children with end-stage renal disease. Despite its benefits, pediatric renal transplantation is a challenge for several transplantation centers in terms of achieving a satisfactory outcome. We sought to compare the long-term outcome of pediatric versus adult recipients who underwent renal transplantation. Method. We examined, 2631 recipients of a first kidney from a living donor between 1982 and 2002. The two groups were matched for immunosuppressive therapy and number of HLA mismatches. The patients were divided into a pediatric (n = 301; age :5 18 years) and an adult group (n = 2330; age > 18 years) to compare 5-year patient and graft survivals. Results. The mean ages of the pediatric and adult groups were 40 +/- 13 and 14 +/- 13 years, respectively. The 5-year graft survival was lower among the pediatric versus the adult group (56 vs 68; P = .015) with no difference in patient survival (88 vs 86; P > .05). Conclusion. The poorer graft survival in pediatric transplantation may be due to the nature of pediatric transplantation, in terms of inconsistent adherence to medication regimens, worse side effects of medications, higher rate of graft rejection due to recurrent disease, and more intense immunoreactivity of children.

Item Type: Article
Keywords: single-center experience renal-transplantation Immunology Surgery Transplantation
Page Range: pp. 1088-1090
Journal or Publication Title: Transplantation Proceedings
Journal Index: ISI
Volume: 39
Number: 4
Identification Number:
ISSN: 0041-1345
Depositing User: مهندس مهدی شریفی

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